Kalo, Eric, Basyouni, Ziad, Meyerowitz Katz, Gideon, Karkvandi, Vahid, Watson, Leanne, Crowther, Helen, Read, Scott, O'Sullivan, Matthew N.V., Ellis, Jasmin, Medlin, Joanne, and Ahlenstiel, Golo (2025) Real-World Effectiveness of Sotrovimab in Patients Infected With SARS-CoV-2 Omicron Subvariant BA.2 in Western Sydney, Australia. Journal of Medical Virology, 97 (2). e70235.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution. Download (505kB) | Preview

Abstract

Laboratory-based findings suggest that Sotrovimab is significantly less effective against emerging CARS-CoV-2 variants, however, clinical data is lacking. Here we examined the effectiveness of sotrovimab, in preventing emergency department (ED) presentation and subsequent hospitalization in high-risk subgroups of patients during the SARS-CoV-2 Delta and Omicron waves in Western Sydney, Australia (n = 515). Risk for ED attendance was comparable in Omicron patients, whether BA.1 or BA.2, compared to Delta patients (hazard ratio of 0.97 [0.36–2.64]). These findings highlight the need for caution when using in vitro findings to drive clinical practice, especially when the consequence is to withhold potentially lifesaving treatment.

Item ID:	86118
Item Type:	Article (Research - C1)
ISSN:	1096-9071
Keywords:	COVID‐19, Delta, hospitalisation, monoclonal, Omicron BA.2, SARS‐CoV‐2, sotrovimab
Copyright Information:	© 2025 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Research Data:	https://onlinelibrary.wiley.com/doi/10.1002/jmv.70235
Date Deposited:	16 Jul 2025 04:56
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320705 Medical virology @ 70% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 20% 42 HEALTH SCIENCES > 4202 Epidemiology > 420299 Epidemiology not elsewhere classified @ 10%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 50% 20 HEALTH > 2003 Provision of health and support services > 200302 Community health care @ 20% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 30%
Downloads:	Total: 1 Last 12 Months: 1
	More Statistics