Kiwanuka, N., Quach, T., Kakaire, R., Zalwango, S., Castellanos Reynosa, M., Sekandi, J., and Whalen, C.C. (2024) Incidence of tuberculous infection in a TB-endemic city. International Journal of Tuberculosis and Lung Disease, 28 (6). pp. 266-272.

PDF (Accepted Publisher Version) - Accepted Version Restricted to Repository staff only

Abstract

BACKGROUND: Current metrics for TB transmission include TB notifications, disease mortality, and prevalence surveys. These metrics are helpful to national TB programs to assess the burden of disease, but they do not directly measure incident infection in the community.

METHODS: To estimate incidence of Mycobacterium tuberculosis infection in Kampala, Uganda, we performed a prospective cohort study between 2014 and 2017 which enrolled of 1,275 adult residents without signs of tuberculous infection (tuberculin skin test [TST],5 mm and no signs of TB disease) and followed them for conversion of TST at 1 year.

RESULTS: During follow-up, 194 participants converted the TST and 158 converted by one year. The incidence density of TST conversion was 13.2 conversions/ 100 person-year (95% CI 11.6–15.1), which corresponds to an annual cumulative incidence of tuberculous infection of 12.4% (95% CI 10.7–14.3). Cumulative incidence was greater among older participants and among men. Among participants who reported prior exposure to TB cases, the cumulative risk was highest among those reporting exposure during follow-up.

CONCLUSIONS: The high annual incidence of infection suggests that residents of Kampala have adequate contact for infection with undetected, infectious cases of TB as they go about their daily lives.

Item ID:	85620
Item Type:	Article (Research - C1)
ISSN:	1815-7920
Keywords:	prospective cohort study, risk factors, TB infection, TB-endemic, tuberculosis, Uganda
Date Deposited:	27 May 2025 03:43
Downloads:	Total: 1 Last 12 Months: 1
	More Statistics