Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease
Mahan, Brandon, Hu, Yan, Lahoud, Esther, Nestmeyer, Mark, McCoy-West, Alex, Manestar, Grace, Fowler, Christopher, Bush, Ashley I., and Moynier, Frédéric (2024) Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease. Metallomics, 16 (9).
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Abstract
The Alzheimer's disease (AD)-affected brain purges K with concurrently increasing serum K, suggesting brain–blood K transferal. Here, natural stable K isotope ratios—δ41K—of human serum samples were characterized in an AD biomarker pilot study (plus two paired Li-heparin and potassium ethylenediaminetetraacetic acid [K-EDTA] plasma samples). AD serum was found to have a significantly lower mean δ41K relative to controls. To mechanistically explore this change, novel ab initio calculations (density functional theory) of relative K isotope compositions between hydrated K+ and organically bound K were performed, identifying hydrated K+ as isotopically light (lower δ41K) compared to organically bound K. Taken together with literature, serum δ41K and density functional theory results are consistent with efflux of hydrated K+ from the brain to the bloodstream, manifesting a measurable decrease in serum δ41K. These data introduce serum δ41K for further investigation as a minimally invasive AD biomarker, with cost, scalability, and stability advantages over current techniques.
| Item ID: | 85479 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1756-591X |
| Copyright Information: | © The Author(s) 2024. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Date Deposited: | 14 May 2025 02:04 |
| FoR Codes: | 37 EARTH SCIENCES > 3703 Geochemistry > 370303 Isotope geochemistry @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320599 Medical biochemistry and metabolomics not elsewhere classified @ 70% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100% |
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