Wang, Yutang, Fang, Yan, Habenicht, Andreas J.R., Golledge, Jonathan, Giovannucci, Edward L., and Ceriello, Antonio (2024) Postprandial Plasma Glucose With a Fasting Time of 4–7.9 h Is Positively Associated With Cancer Mortality in US Adults. Diabetes/Metabolism Research and Reviews, 40 (8). e70008.

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Abstract

Aims: This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults.

Materials and Methods: This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up until December 31, 2019. The explanatory variable was the level of plasma glucose, including PPG with a fasting time of 0–3.9 h (PPG0–3.9h) and 4–7.9 h (PPG4–7.9h), plasma glucose with a fasting time ≥8 h (PGfasting), and plasma glucose at 2 h after oral glucose tolerance test (PG2hOGTT). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazard models.

Results: A 1-natural-log-unit increase in PPG4–7.9h was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, PPG0–3.9h, PGfasting, PG2hOGTT, haemoglobin A1c, and insulin were not significantly associated with cancer mortality. The positive association of PPG4–7.9h with cancer mortality remained in those without a prior diagnosis of cancer.

Conclusions: High PPG4–7.9h is associated with a higher cancer mortality risk in US adults. Lowering PPG4–7.9h may reduce cancer mortality.

Item ID:	85164
Item Type:	Article (Research - C1)
ISSN:	1520-7560
Keywords:	cancer, glucose, mortality, post-meal, postprandial
Copyright Information:	© 2024 John Wiley & Sons Ltd.
Date Deposited:	22 Apr 2025 01:14
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320208 Endocrinology @ 70% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321109 Predictive and prognostic markers @ 30%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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