Smout, Michael J., Laha, Thewarach, Chaiyadet, Sujittra, Brindley, Paul J., and Loukas, Alex (2024) Mechanistic insights into liver-fluke-induced bile-duct cancer. Trends in Parasitology, 40. pp. 1183-1196.

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Abstract

Liver fluke infection is a major risk for cholangiocarcinoma (CCA). It has been established that the Asian liver flukes, Clonorchis sinensis and Opisthorchis viverrini secrete growth factors, digestive enzymes, and extracellular vesicles (EVs) which contribute to abnormal cell development in the bile ducts where the worms reside. These secretions – combined with aberrant inflammation and repeated cycles of chronic wounding at the site of parasite attachment and grazing on the epithelium – promote biliary hyperplasia and fibrosis and ultimately malignant transformation. Application of post-genomic and gene-editing tools to the study of liver fluke immunobiology and pathogenesis has accelerated the discovery of essential virulence factors to which targeted therapies and diagnostics can be directed.

Item ID:	85155
Item Type:	Article (Research - C1)
ISSN:	1471-5007
Copyright Information:	© 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC 2008450
Date Deposited:	21 Apr 2025 23:31
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50% 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50%
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