T cell dominance in malaria and COVID-19
Browne, Daniel Joseph (2024) T cell dominance in malaria and COVID-19. PhD thesis, James Cook University.
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Abstract
Daniel Browne optimised a high-throughput screening method to identify immunodominant T cell epitopes in malaria and COVID-19, offering crucial insights to improve vaccine design.
| Item ID: | 85000 |
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| Item Type: | Thesis (PhD) |
| Keywords: | COVID-19, T cell dominance, immunisation, vaccines, Malaria |
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| Copyright Information: | Copyright © 2024 Daniel Joseph Browne |
| Additional Information: | Four publications arising from this thesis are stored in ResearchOnline@JCU, at time of processing. Please see the Related URLS. The publications are: [Chapter 2] Browne, Daniel J., Brady, Jamie L., Van Waardenberg, Ashley J., Loiseau, Claire, and Doolan, Denise L. (2020) An analytically and diagnostically sensitive RNA extraction and RT-qPCR protocol for peripheral blood mononuclear cells. Frontiers in Immunology, 11. 402. [Chapter 3] Browne, Daniel J., Kelly, Ashton M., Brady, Jamie L., and Doolan, Denise L. (2022) A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs. Frontiers in Immunology, 13. 962220. [Chapter 4] Browne, Daniel J., Kelly, Ashton M., Brady, Jamie, Proietti, Carla, Sarathkumara, Yomani D., Pattinson, David J., and Doolan, Denise L. (2023) Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. Scientific Reports, 13. 21071. [Chapter 7] Browne, Daniel J., Miller, Catherine M., and Doolan, Denise L. (2024) Technical pitfalls when collecting, cryopreserving, thawing, and stimulating human T-cells. Frontiers in Immunology, 15. 1382192. |
| Date Deposited: | 31 Mar 2025 05:23 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320402 Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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