Ross, Ailie, Wight, Joel, and Rudd, Donna (2025) Low flow: Selecting a limited flow cytometry panel where resources are constrained. Blood Reviews. 101284. (In Press)

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Abstract

Diagnosis and treatment of patients with haematological malignancies (HM) is hampered by access to pathology services in resource-limited settings (RLS). Internationally accepted guidelines and diagnostic criteria for HM require access to sophisticated analysis including comprehensive flow cytometry (FCM) for minimum essential diagnosis and treatment, which is technically challenging in RLS. This review will define these shortcomings and examine the use of limited FCM panels in RLS. While a consensus guideline exists for a limited chronic lymphocytic leukaemia (CLL) FCM panel, this has yet to be validated in a large cohort. Currently, there are no consensus-based and resource-stratified diagnostic protocols defining limited FCM panels for the diagnosis of acute leukaemia where resources are limited. There is an unmet need for such guidelines, supported by evidence, for the diagnosis of the most common HM. This systematic review defines consensus-based limited FCM panels from the literature that may be used in the interim.

Item ID:	84996
Item Type:	Article (Research - C1)
ISSN:	1532-1681
Copyright Information:	Copyright © 2025 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Date Deposited:	27 Mar 2025 00:00
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320102 Haematology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 50% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50%
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