Davidson, Mikaeylah J., Kosch, Tiffany A., Aquilina, Amy, Webb, Rebecca J., Skerratt, Lee F., and Berger, Lee (2025) Influence of Batrachochytrium dendrobatidis isolate and dose on infection outcomes in a critically endangered Australian amphibian. Fungal Ecology, 73. 101397.

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Abstract

The amphibian chytrid fungus (Batrachochytrium dendrobatidis (Bd)) is a continuing threat globally, causing widespread declines. Corroboree frogs (Pseudophryne corroboree) are critically endangered and no longer have self-sustaining populations in the wild due to the presence of Bd in the environment. We aimed to investigate variation in susceptibility to Bd in juvenile P. corroboree and evaluate the impact of Bd isolate and dose on infection outcomes. We experimentally exposed juvenile P. corroboree to two Bd isolates at five doses, and also characterised the in vitro growth of these isolates. Frogs showed high susceptibility to Bd, with isolate and dose impacting survival time and infection loads. Additionally, differences in the in vitro phenotype of the two Bd isolates were linked to their differential virulence. This study highlights the considerable impact that fungal isolate and dose have in shaping disease outcomes in experimental exposures.

Item ID:	84910
Item Type:	Article (Research - C1)
ISSN:	1878-0083
Copyright Information:	© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Funders:	Australian Research Council (ARC)
Projects and Grants:	ARC grant FT190100462, ARC grant LP200301370
Date Deposited:	18 Mar 2025 00:04
FoR Codes:	41 ENVIRONMENTAL SCIENCES > 4104 Environmental management > 410401 Conservation and biodiversity @ 50% 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 50%
SEO Codes:	18 ENVIRONMENTAL MANAGEMENT > 1806 Terrestrial systems and management > 180602 Control of pests, diseases and exotic species in terrestrial environments @ 100%
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