Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework
Sarnyai, Zoltan, and Ben-Scachar, Dorit (2024) Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework. Psychiatry Research, 342. 116220.
|
PDF (Published Version)
- Published Version
Available under License Creative Commons Attribution. Download (4MB) | Preview |
Abstract
Schizophrenia is a chronic, neurodevelopmental disorder with unknown aetiology and pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities in synaptic plasticity. The currently used pharmacological approach, the antipsychotic drugs, which have limited efficacy and an array of side-effects, have been developed based on the neurotransmitter hypothesis. Recent research has uncovered systemic and brain abnormalities in glucose and energy metabolism, focusing on altered glycolysis and mitochondrial oxidative phosphorylation. These findings call for a re-conceptualisation of schizophrenia pathophysiology as a progressing bioenergetics failure. In this review, we provide an overview of the fundamentals of brain bioenergetics and the changes identified in schizophrenia. We then propose a new explanatory framework positing that schizophrenia is a disease of impaired dynamic metabolic flexibility, which also reconciles findings of abnormal glucose and energy metabolism in the periphery and in the brain along the course of the disease. This evidence-based framework and testable hypothesis has the potential to transform the way we conceptualise this debilitating condition and to develop novel treatment approaches.
| Item ID: | 84829 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1872-7123 |
| Keywords: | Aerobic glycolysis, Brain and periphery, Dynamic energy metabolism, Mitochondrial oxidative phosphorylation, Schizophrenia |
| Related URLs: | |
| Copyright Information: | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Date Deposited: | 06 Mar 2025 01:36 |
| More Statistics |
Actions (Repository Staff Only)
 |
Item Control Page |