Insecticide-treated nets and protection against Insecticide-Resistant malaria vectors in Western Kenya
Ochomo, Eric, Chahilu, Mercy, Cook, Jackie, Kinyari, Teresa, Bayoh, Nabie M., West, Philippa, Kamau, Luna, Osangle, Aggrey, Ombok, Maurice, Njagi, Kiambo, Mathenge, Evan, Muthami, Lawrence, Subramaniam, Krishanthi, Knox, Tessa, Mnavaza, Abraham, Donnelly, Martin James, Kleinschmidt, Immo, and Mbogo, Charles (2017) Insecticide-treated nets and protection against Insecticide-Resistant malaria vectors in Western Kenya. Emerging Infectious Diseases, 25 (5). pp. 758-764.
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Abstract
Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9-2.5) infections/person-year and 2.8 (95% CI 2.5-3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42-0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35-0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance.
| Item ID: | 84681 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1080-6059 |
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| Copyright Information: | Emerging Infectious Diseases is an open access journal in the public domain. All content is freely available without charge to the user or his/her institution. Materials published in EID, including text, figures, tables, and photographs, can be reprinted or reused although the journal requests a proper citation be included for its content and users clearly indicate what, if any, changes have been made. |
| Date Deposited: | 19 Feb 2025 23:46 |
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