Mosimann, Vincent, Neumayr, Andreas, Paris, Daniel H., and Blum, Johannes (2018) Liposomal amphotericin B treatment of Old World Cutaneous and Mucosal Leishmaniasis: A literature review. Acta Tropica, 182. pp. 246-250.

PDF (Published Version) - Published Version Restricted to Repository staff only

Abstract

Old World cutaneous and mucosal leishmaniasis is a potentially serious disease. Systemic treatment approaches with pentavalent antimonials, liposomal amphotericin B, fluconazole and miltefosine are increasingly used despite the absence of supportive evidence − to date, no prospective clinical trials have been conducted for systemic treatment of these diseases.

We performed a literature search to delineate the contemporary evidence for the use of liposomal amphotericin B, and found that although cure rates of 17/20 (85%) were achieved in immune competent patients with Old World cutaneous leishmaniasis and cure rates of 10/13 (77%) for Old World mucosal leishmaniasis due to L. infantum, the available data is highly limited with high variation in total treatment dosages. The presented findings reflect a lack of consensus on the optimal treatment dosage and on the schedule of application.

Item ID:	84509
Item Type:	Article (Research - C1)
ISSN:	1873-6254
Copyright Information:	© 2018 Elsevier B.V. All rights reserved.
Date Deposited:	27 Jan 2025 22:27
Downloads:	Total: 2 Last 12 Months: 2
	More Statistics