Hong, Yaoqin, Liu, Michael A., and Reeves, Peter R. (2018) Progress in our understanding of Wzx flippase for translocation of bacterial membrane lipid-linked oligosaccharide. Journal of Bacteriology, 200 (1). e00154-17.

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Abstract

Translocation of lipid-linked oligosaccharides is a common theme across prokaryotes and eukaryotes. For bacteria, such activity is used in cell wall construction, polysaccharide synthesis, and the relatively recently discovered protein glycosylation. To the best of our knowledge, the Gram-negative inner membrane flippase Wzx was the first protein identified as being involved in oligosaccharide translocation, and yet we still have only a limited understanding of this protein after 3 decades of research. At present, Wzx is known to be a multitransmembrane protein with enormous sequence diversity that flips oligosaccharide substrates with varied degrees of preference. In this review, we provide an overview of the major findings for this protein, with a particular focus on substrate preference.

Item ID:	83816
Item Type:	Article (Research - C1)
ISSN:	1098-5530
Related URLs:	http://www.scopus.com/inward/record.url?...
Copyright Information:	Copyright © 2017 American Society for Microbiology. All Rights Reserved.
Date Deposited:	16 Oct 2024 03:01
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