Hong, Yaoqin, Qin, Jilong, and Totsika, Makrina (2023) A conditional nature for the synthetical lethality between defects in lipid and peptidoglycan biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 120 (52). e2318882120.

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Abstract

[Extract] We write to provide an alternative view on the synthetic lethality between lipid and peptidoglycan synthesis (fabH and nlpI) reported in a recent PNAS article, “Cross-talk between phospholipid synthesis and peptidoglycan expansion by a cell wall hydrolase” by Som and Reddy (1). Our viewpoint centers on the conditional nature of this lethality, driven by the weakened cell envelope's inability to withstand compressive turgor pressure.

Item ID:	83805
Item Type:	Article (Commentary)
ISSN:	1091-6490
Copyright Information:	Copyright © 2023 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Date Deposited:	16 Oct 2024 23:48
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