A conditional nature for the synthetical lethality between defects in lipid and peptidoglycan biosynthesis
Hong, Yaoqin, Qin, Jilong, and Totsika, Makrina (2023) A conditional nature for the synthetical lethality between defects in lipid and peptidoglycan biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 120 (52). e2318882120.
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Abstract
[Extract] We write to provide an alternative view on the synthetic lethality between lipid and peptidoglycan synthesis (fabH and nlpI) reported in a recent PNAS article, “Cross-talk between phospholipid synthesis and peptidoglycan expansion by a cell wall hydrolase” by Som and Reddy (1). Our viewpoint centers on the conditional nature of this lethality, driven by the weakened cell envelope's inability to withstand compressive turgor pressure.
| Item ID: | 83805 |
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| Item Type: | Article (Commentary) |
| ISSN: | 1091-6490 |
| Copyright Information: | Copyright © 2023 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). |
| Date Deposited: | 16 Oct 2024 23:48 |
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