Valencia-Hernandez, Ana Maria, Zhao, Guangzu, Miranda-Hernandez, Socorro, Segura-Cerda, Cristian Alfredo, Pedroza-Roldan, Cesar, Seifert, Julia, Aceves-Sanchez, Michel de Jesus, Burciaga-Flores, Mirna, Gutierrez-Ortega, Abel, del Pozo-Ramos, Lidia Maria, Flores-Valdez, Mario Alberto, and Kupz, Andreas (2024) A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts. Vaccine, 42. 126291.

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Abstract

Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, we reported two recombinant BCG strains effective against murine TB with low virulence and lung pathology in immunocompromised mice and guinea pigs. We have recently combined these two recombinant BCG strains into one novel vaccine candidate (BCGΔBCG1419c::ESAT6-PE25SS) and evaluated its immunogenicity, efficacy and safety profile in mice. This new vaccine candidate is non-inferior to BCG in protection against TB, presents reduced pro-inflammatory immune responses and displays an enhanced safety profile.

Item ID:	83715
Item Type:	Article (Research - C1)
ISSN:	1873-2518
Keywords:	Immunocompromised mice, Recombinant BCG, Tuberculosis, Vaccine development
Related URLs:	https://www.scopus.com/inward/record.uri...
Copyright Information:	© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC APP2008715
Date Deposited:	23 Sep 2024 23:34
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