Chowdhury, Dibakar, Nayeem, Md., Vanderven, Hillary A., and Sarker, Subir (2024) Role of miRNA in Highly Pathogenic H5 Avian Influenza Virus Infection: An Emphasis on Cellular and Chicken Models. Viruses, 16 (7). 1102.

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Abstract

The avian influenza virus, particularly the H5N1 strain, poses a significant and ongoing threat to both human and animal health. Recent outbreaks have affected domestic and wild birds on a massive scale, raising concerns about the virus’ spread to mammals. This review focuses on the critical role of microRNAs (miRNAs) in modulating pro-inflammatory signaling pathways during the pathogenesis of influenza A virus (IAV), with an emphasis on highly pathogenic avian influenza (HPAI) H5 viral infections. Current research indicates that miRNAs play a significant role in HPAI H5 infections, influencing various aspects of the disease process. This review aims to synthesize recent findings on the impact of different miRNAs on immune function, viral cytopathogenicity, and respiratory viral replication. Understanding these mechanisms is essential for developing new therapeutic strategies to combat avian influenza and mitigate its effects on both human and animal populations.

Item ID:	83519
Item Type:	Article (Research - C1)
ISSN:	1999-4915
Keywords:	avian influenza virus,H5 subtypes,miRNA
Related URLs:	https://www.scopus.com/inward/record.uri...
Copyright Information:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Funders:	Australian Research Council (ARC)
Projects and Grants:	ARC Discovery Early Career Researcher Award (grant number DE200100367)
Date Deposited:	02 Sep 2024 23:03
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