Tristram, Stephen G., Littlejohn, Rachael, and Bradbury, Richard S. (2010) bla ROB-1 Presence on pB1000 in Haemophilus influenzae Is Widespread, and Variable Cefaclor Resistance Is Associated with Altered Penicillin-Binding Proteins. Antimicrobial Agents and Chemotherapy, 54 (11). pp. 4945-4947.

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Abstract

Plasmid pB1000 is a small replicon recently identified as bearing blaROB-1 in animal and human Pasteurellaceae in Spain. We identified pB1000 in 11 blaROB-1-positive Australian and North American Haemophilus influenzae isolates, suggesting a wider role for pB1000 in disseminating blaROB-1. Native H. influenzae conjugative elements can mobilize plasmids similar to pB1000 at a low frequency of 10−8, and this might account for the infrequency of blaROB-1 compared to the rate of occurrence of blaTEM-1. Altered penicillin-binding protein 3 was associated with an increased cefaclor MIC in 3 isolates.

Item ID:	83386
Item Type:	Article (Research - C1)
ISSN:	1098-6596
Copyright Information:	© 2010 American Society for Microbiology.
Date Deposited:	20 Aug 2024 05:16
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