Omatola, Cornelius Arome, Ogunsakin, Ropo Ebenezer, Onoja, Anyebe Bernard, Okolo, Martin-Luther Oseni, Abraham-Oyiguh, Joseph, Mofolorunsho, Kehinde Charles, Akoh, Phoebe Queen, Adejo, Omebije Patience, Idakwo, Joshua, Therisa Ojomideju Okeme, Muhammed, Danjuma, Adaji, David Moses, Samson, Sunday Ocholi, Aminu, Ruth Foluke, Akor, Monday Eneojo, Edegbo, Emmanuel, and Adamu, Andrew Musa (2024) Enteropathogenic viruses associated with acute gastroenteritis among African children under 5 years of age: A systematic review and meta-analysis. Journal of Infection, 88. 106169.

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Abstract

Gastroenteritis viruses are the leading etiologic agents of diarrhea in children worldwide. We present data from thirty-three (33) eligible studies published between 2003 and 2023 from African countries bearing the brunt of the virus-associated diarrheal mortality. Random effects meta-analysis with proportion, subgroups, and meta-regression analyses were employed. Overall, rotavirus with estimated pooled prevalence of 31.0 % (95 % CI 24.0–39.0) predominated in all primary care visits and hospitalizations, followed by norovirus, adenovirus, sapovirus, astrovirus, and aichivirus with pooled prevalence estimated at 15.0 % (95 % CI 12.0–20.0), 10 % (95 % CI 6–15), 4.0 % (95 % CI 2.0–6.0), 4 % (95 % CI 3–6), and 2.3 % (95 % CI 1–3), respectively. Predominant rotavirus genotype was G1P[8] (39 %), followed by G3P[8] (11.7 %), G9P[8] (8.7 %), and G2P[4] (7.1 %); although, unusual genotypes were also observed, including G3P[6] (2.7 %), G8P[6] (1.7 %), G1P[6] (1.5 %), G10P[8] (0.9 %), G8P[4] (0.5 %), and G4P[8] (0.4 %). The genogroup II norovirus predominated over the genogroup I-associated infections (84.6 %, 613/725 vs 14.9 %, 108/725), with the GII.4 (79.3 %) being the most prevalent circulating genotype. In conclusion, this review showed that rotavirus remains the leading driver of viral diarrhea requiring health care visits and hospitalization among under-five years children in Africa. Thus, improved rotavirus vaccination in the region and surveillance to determine the residual burden of rotavirus and the evolving trend of other enteric viruses are needed for effective control and management of cases.

Item ID:	82693
Item Type:	Article (Research - C1)
ISSN:	1532-2742
Copyright Information:	© 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Date Deposited:	08 May 2024 03:57
FoR Codes:	42 HEALTH SCIENCES > 4206 Public health > 420601 Community child health @ 100%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200404 Disease distribution and transmission (incl. surveillance and response) @ 100%
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