Sikder, Suchandan, Pierce, Doris, Sarkar, Eti R., McHugh, Connor, Quinlan, Kate G.R., Giacomin, Paul, and Loukas, Alex (2024) Regulation of host metabolic health by parasitic helminths. Trends in Parasitology, 40 (5). pp. 386-400.

PDF (Author Accepted Version) - Accepted Version Restricted to Repository staff only until 11 April 2025.

Abstract

Obesity is a worldwide pandemic and major risk factor for the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). T2D requires lifelong medical support to limit complications and is defined by impaired glucose tolerance, insulin resistance (IR), and chronic low-level systemic inflammation initiating from adipose tissue. The current preventative strategies include a healthy diet, controlled physical activity, and medication targeting hyperglycemia, with underexplored underlying inflammation. Studies suggest a protective role for helminth infection in the prevention of T2D. The mechanisms may involve induction of modified type 2 and regulatory immune responses that suppress inflammation and promote insulin sensitivity. In this review, the roles of helminths in counteracting MetS, and prospects for harnessing these protective mechanisms for the development of novel anti-diabetes drugs are discussed.

Item ID:	82614
Item Type:	Article (Research - C1)
ISSN:	1471-4922
Copyright Information:	© 2024 Elsevier Ltd. All rights reserved.
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC 2008450
Date Deposited:	13 Jun 2024 03:07
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320504 Medical biochemistry - lipids @ 20% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 30%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200411 Overweight and obesity @ 100%
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