Next-Generation Vaccines for Tropical Infectious Diseases

Allen, Tammy, Castellanos Reynosa, Maria, Giacomin, Paul, Karunaweera, Nadira D., Kupz, Andreas, Carlos LoL, Juan, Sharma, Dileep, Sikder, Suchandan, Tedla, Bemnet, van Eijk, Liza, Vojisavljevic, Danica, Zhao, Guangzu, and Pai, Saparna (2024) Next-Generation Vaccines for Tropical Infectious Diseases. International Journal of Infectious Diseases, 143. 107014.

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Abstract

Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. While anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases, but these have been difficult to develop, mostly due to the complex nature of the pathogen lifecycles. Here, we present recently developed vaccine candidates for five tropical infectious diseases in the form of a catalogue, that have either entered clinical trials or have been licenced for use. We deliberate on recently licensed dengue vaccines; provide evidence why combination vaccination could have a synergistic impact on schistosomiasis; critically appraise the value of typhoid conjugate vaccines; and discuss the potential of vaccines in the efforts to eliminate vivax malaria and hookworms.

Item ID: 82476
Item Type: Article (Research - C1)
ISSN: 1878-3511
Copyright Information: © 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Investigator Grant APP2008715
Date Deposited: 18 Apr 2024 04:14
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320699 Medical biotechnology not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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