Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia

Blanco, Gonzalo, Morris, Edward, Morris, Jodie L., Letson, Hayley L., Susheel, Suvarna, Puiggros, Anna, Espinet, Blanca, Chiorazzi, Nicholas, and Dobson, Geoffrey P. (2024) Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia. Annals of Case Reports, 9. 101539.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (1MB) | Preview
View at Publisher Website: https://doi.org/10.29011/2574-7754.10153...
 
31


Abstract

Spontaneous regression (SR) of chronic lymphocytic leukemia (CLL) is a rare event (0.2% - 1%). Some advances have been made in understanding the tumor genetic characteristics of such patients, although the immunological mechanisms leading to SR remain unclear. We describe a series of immunological events related to regression dynamics, allowing the identification of a SR phase (associated with >99% reduction of CLL cells in peripheral blood and adenopathy resolution in less than one year, concurrently with a nine-fold increase in monocyte counts, high B2M and the appearance of an oligoclonal serum IgG band), followed by a persistent regression (PR) phase that was maintained for ≥17 months. Our observations highlight a role of monocytes and B2M in SR, potentially related to immune activation. The oligoclonal IgG band detected during SR was maintained in PR, suggesting either a change in the ability of malignant cells (IgM+IgD+IgG‒) to differentiate into IgG-secreting cells, or an anti-tumor humoral response from normal B cells. These findings imply immune and molecular mechanisms required to eliminate malignant cells and might suggest new immunotherapies for CLL.

Item ID: 82416
Item Type: Article (Other)
ISSN: 2574-7754
Keywords: Spontaneous Regression (SR); Persistent Regression (PR); Monocytes; β-2 Microglobulin (B2M); Immunoglobulin G (IgG)
Related URLs:
Copyright Information: © 2024 by the Authors & Gavin Publishers. This is an Open Access Journal Article Published Under Attribution-Share Alike CC BY-SA: Creative Commons Attribution-Share Alike 4.0 International License. With this license, readers can share, distribute, download, even commercially, as long as the original source is properly cited.
Date Deposited: 14 May 2024 01:33
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321106 Haematological tumours @ 90%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321109 Predictive and prognostic markers @ 10%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
Downloads: Total: 31
Last 12 Months: 7
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page