Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy
Wang, Feng, Xing, Tao, Wang, Niansong, and Liu, Limei (2012) Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy. Cytokine, 57 (1). pp. 127-129.
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Abstract
Objective: To investigate the levels of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy at different stages.
Methods: A total of 80 patients with type 2 diabetes mellitus were enrolled in the present study. According to 24 h urinary albumin excretion ratio and renal function, they were further divided into group of diabetes without microalbuminuria (DN0, n = 20), microalbuminuria group (DN1, n = 20), macroalbuminuria group (DN2, n = 20) and renal insufficiency group (DN3, n = 20). Another 20 healthy subjects were enrolled as control group (non-DM). Plasma CD146 and P-selectin were measured by ELISA.
Results: Plasma CD146 and P-selectin were significantly increased in patients with type 2 diabetes with microalbuminuria (DN1) compared with health control (CD146: 415.3 ± 29.0 vs. 243.5 ± 14.7 ng/ml, P < 0.05; P-selectin: 66.8 ± 3.4 vs. 45.3 ± 2.7 ng/ml, P < 0.001). With the development of diabetic nephropathy, both plasma CD146 and P-selectin level progressively rise, with the highest levels in patients with significant renal insufficiency (DN3: 515.9 ± 36.9 and 81.5 ± 5.1 ng/ml respectively, P < 0.001). Moreover, the increase in CD146 is positively co-related to the rise of P-selectin in patients with type 2 diabetes.
Conclusion: Expression of CD146 and P-selectin in patients with type 2 diabetes is elevated, and they are positively correlated with severity of diabetic nephropathy.
| Item ID: | 82175 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1096-0023 |
| Keywords: | CD146, P-selectin, CRP, Type 2 diabetes mellitus, Diabetic nephropathy |
| Copyright Information: | © 2011 Elsevier Ltd. All rights reserved. |
| Date Deposited: | 25 Jun 2024 05:53 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 100% |
| SEO Codes: | 20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100% |
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