Wang, Feng, Li, Junhui, Xing, Tao, Xie, Yuting, and Wang, Niansong (2014) Serum renalase is related to catecholamine levels and renal function. Clinical and Experimental Nephrology, 19. pp. 92-98.

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Abstract

Background: Renalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Although it has been shown that serum renalase level significantly decreases with impaired renal function, it is not clear whether its level is related to different stages of chronic kidney disease (CKD) in patients.

Methods: Eighty-seven patients with CKD were selected as subjects of this study to investigate the serum renalase and catecholamine (CA) levels by ELISA method, and their relationship with other renal function indicators.

Results: Serum levels of renalase and renalase–catecholamine (R/C) ratios were significantly higher in CKD stage 3–5 patients (217.4 ± 103.8 ng/L, 1.00 ± 0.21) than CKD stage 1–2 patients (162.1 ± 40.1 ng/L, 0.82 ± 0.16; P < 0.05), while there was no significant difference between CKD stage 1–2 patients and the normal control group (167.8 ± 69.4 ng/L, 0.88 ± 0.17; P > 0.05). Renalase levels were linearly correlated with catecholamine levels (R 2 = 0.817; P < 0.01). Serum renalase levels were positively correlated with systolic blood pressure (SBP), serum CA, BUN, SCr, UA, and CKD stage (P < 0.05), while negatively correlated with RBC, Hb and estimated GFR (eGFR) (P < 0.05). R/C ratio was positively correlated with SBP, diastolic blood pressure, BUN, SCr, UA, cystatin C, β2 microglobulin, retinol binding protein-4 and CKD stage (P < 0.05), while negatively correlated with RBC, Hb, eGFR and GFR (P < 0.05).

Conclusions: Serum levels of renalase are highly correlated with CA and both serum renalase levels and R/C ratios are related to renal function.

Item ID:	82167
Item Type:	Article (Research - C1)
ISSN:	1437-7799
Copyright Information:	© Japanese Society of Nephrology 2014.
Date Deposited:	10 Jul 2024 01:23
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 50%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
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