Wang, Feng, Zhang, Guangyuan, Zhou, Yang, Gui, Dingkun, Li, Junhui, Xing, Tao, and Wang, Niansong (2014) Magnolin protects against contrast induced nephropathy in rats via anti-oxidation and anti-apoptosis. Oxidative Medicine and Cellular Longevity, 2014. 203458.

PDF (Published Version) - Published Version Restricted to Repository staff only

Abstract

Background. Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties.

Methods. To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis, in vivo and in vitro, we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H2O2. Rats were assigned to 4 groups (n = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin).

Results. The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function (P < 0.05). Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expression in vivo and in vitro.

Conclusion. Magnolin might protect CIN in rats through antioxidation and antiapoptosis.

Item ID:	82163
Item Type:	Article (Research - C1)
ISSN:	1942-0994
Copyright Information:	Copyright © 2014 Feng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date Deposited:	17 Jul 2024 02:33
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 100%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
	More Statistics