Xing, D., Siva, S., and Hanna, G.G. (2019) The abscopal effect of stereotactic radiotherapy and immunotherapy – fool’s gold or el dorado? Clinical Oncology, 31 (7). pp. 432-443.

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Abstract

An ‘abscopal’ effect if often used to refer to distant tumour regression after localised irradiation. Since the first report of the abscopal effect in the 1950s, well-documented cases with radiotherapy alone are very rare. It is widely accepted that the immune response plays an important role in the abscopal effect, although the mechanism is still unclear. With the recent success of cancer immunotherapy, there is growing interest in combining immunotherapy with radiotherapy to boost abscopal response rates. Compared with conventional radiotherapy, stereotactic ablative radiotherapy (SABR) not only delivers ablative dose to the tumour, but may also induce robust immune responses. In this review we examine studies that combine SABR and immunotherapy. We review the preclinical rationale for SABR and immunotherapy combinations, the case for and against abscopal effects, and the current landscape of clinical trials.

Item ID:	82160
Item Type:	Article (Research - C1)
ISSN:	1433-2981
Keywords:	Abscopal; immunotherapy; oligometastatic; radiotherapy; stereotactic
Copyright Information:	© 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Date Deposited:	26 Mar 2024 03:32
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321104 Cancer therapy (excl. chemotherapy and radiation therapy) @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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