Xing, Daniel, Tiong, Albert, Bressel, Mathias, Rischin, Danny, Tran, Philip, and Corry, June (2020) Outcomes of curative (chemo)radiotherapy for patients with non-p16 positive head and neck squamous cell carcinoma who are borderline for curative treatment. Journal of Medical Imaging and Radiation Oncology, 64 (2). pp. 271-278.

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Abstract

Introduction: Appropriate selection of head and neck squamous cell cancer (HNSCC) patients for curative treatment is difficult, and it is a very understudied issue. The aim of this study was to review the outcomes of curative intent treatment in non-p16 positive HNSCC patients assessed as having borderline curability.

Methods: A single institution retrospective review of the clinical outcomes of non-p16 positive HNSCC patients with borderline curability. Predefined criteria for borderline curability were as follows: (i) T4 and/or N3 disease; or (ii) ECOG status ≥2; or (iii) age ≥75 years.

Results: A total of 114 patients were identified. A total of 56 had N3/T4, 32 were >ECOG 2 and 57 were >75 years. A total of 29 had two or more borderline curability criteria. Progression-free survival rate (PFS) at 1 and 2 years was 72% (95% confidence interval (CI), 63–79) and 53% (95% CI, 43–62), respectively. Overall survival (OS) at 1 and 2 years was 76% (95% CI, 67–83) and 61% (95% CI, 51–69), respectively. On multivariable analysis, the only independent prognostic factor for OS was the adult comorbidity evaluation-27 (ACE-27) grade (HR 1.4; 95% CI, 1.1–1.8; P = 0.018).

Conclusions: Patients with borderline curability criteria treated with curative intent achieved good PFS and OS. ACE-27 was an important prognostic factor in this population.

Item ID:	82140
Item Type:	Article (Research - C1)
ISSN:	1754-9485
Copyright Information:	© 2020 The Royal Australian and New Zealand College of Radiologists.
Date Deposited:	22 Feb 2024 01:15
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321104 Cancer therapy (excl. chemotherapy and radiation therapy) @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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