More parasitic myositis cases in humans in Australia, and the definition of genetic markers for the causative agents as a basis for molecular diagnosis

Koehler, Anson V., Spratt, David M., Norton, Robert, Warren, Sanchia, McEwan, Belinda, Urkude, Ravindra, Murthy, Suresh, Robertson, Thomas, McCallum, Naomi, Parsonson, Fiona, Bradbury, Richard S., and Gasser, Robin B. (2016) More parasitic myositis cases in humans in Australia, and the definition of genetic markers for the causative agents as a basis for molecular diagnosis. Infection, Genetics and Evolution, 44. pp. 69-75.

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Abstract

Since 1998, there have been six reported human cases of myositis in Australia, attributable to infection with the nematode Haycocknema perplexum. However, an unequivocal diagnosis of H. perplexum infection and associated disease has been seriously compromised by a lack of molecular markers for this nematode. Here, we report new cases of disseminated myositis in two male patients from the states of Queensland and Tasmania in Australia, respectively; genetically characterize the causative agent from each case; and, also establish a PCR-based sequencing approach as a tool to support the diagnosis of future cases and to underpin epidemiological studies.

Item ID: 81874
Item Type: Article (Research - C1)
ISSN: 1567-7257
Keywords: Australia, Disseminated myositis, Haycocknema perplexum, Human, Nematode
Copyright Information: © 2016 Elsevier B.V. All rights reserved.
Date Deposited: 20 Jun 2024 03:24
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 80%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 20%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200404 Disease distribution and transmission (incl. surveillance and response) @ 100%
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