Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis

Wassmer, Samuel C., de Koning-ward, Tania F., Grau, Georges E.R., and Pai, Saparna (2024) Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis. Trends in Parasitology, 40 (1). pp. 28-44.

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Abstract

Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses in CM, with a focus on the role of the perivascular macrophage–endothelium unit in antigen presentation, in the vascular and perivascular compartments. We suggest that these events may be pivotal in the development of CM.

Item ID: 81442
Item Type: Article (Research - C1)
ISSN: 1471-5007
Keywords: antigen presentation, blood–brain barrier disruption, cerebral malaria, pathogenesis, perivascular macrophages
Copyright Information: © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Funders: James Cook University (JCU), National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC)
Projects and Grants: JCU Australian Institute of Tropical Health and Medicine (AITHM), NHMRC APP1099920, ARC DP180102741, ARC DP210101632
Date Deposited: 07 Jan 2024 23:29
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 50%
31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 25%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 25%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 40%
20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 40%
20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 20%
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