Fortier, Emmanuel, Alavi, Maryam, Bruneau, Julie, Micallef, Michelle, Perram, Jacinta, Sockalingam, Sanjeev, Dunlop, Adrian J., Balcomb, Annie C., Day, Carolyn A., Treloar, Carla, Bath, Nicky, Haber, Paul S., Dore, Gregory J., Grebely, Jason, and ETHOS Study Group, (2017) Depression, Anxiety, and Stress Among People With Chronic Hepatitis C Virus Infection and a History of Injecting Drug Use in New South Wales, Australia. Journal of Addiction Medicine, 11 (1). pp. 10-18.

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Abstract

Objective: The aims of this study were to assess symptoms of depression, anxiety, and stress and associated sociodemographic factors among people living with chronic hepatitis C virus (HCV) infection with a history of injecting drug use and to assess the association between symptoms of depression, anxiety, or stress and HCV treatment intent, specialist assessment, or treatment uptake.

Methods: The Enhancing Treatment for Hepatitis C in Opioid Substitution Settings was an observational cohort study evaluating the provision of HCV assessment and treatment among people with chronic HCV and a history of injecting drug use, recruited from 9 community health centers and opioid substitution therapy (OST) clinics (New South Wales, Australia). Symptoms were assessed using the Depression Anxiety Stress Scales (DASS-21). Analyses were performed using logistic regression.

Results: Among 415 participants (mean age 41 years, 71% male), 47%, 52%, and 36% demonstrated moderate to extremely severe symptoms of depression, anxiety, and stress, respectively. In adjusted analyses, depression symptoms were associated with recent injecting drug use adjusted odds ratio (aOR) 1.63, 95% confidence interval (CI) 1.07-2.49), whereas stress symptoms were associated with unemployment (aOR 2.99, 95% CI 1.09-8.15) and not living with a spouse or other relatives/friends (aOR 1.55, 95% CI 1.01-2.39). Symptoms of depression, anxiety, or stress or having a history of treated mental illness were not independently associated with HCV treatment intent, specialist assessment, or treatment uptake.

Conclusions: Findings suggest a need for improved interventions and care regarding mental health among people living with chronic HCV with a history of injecting drug use, but suggest that symptoms of depression, anxiety, and stress should not be immediate contraindications to HCV assessment and treatment.

Item ID:	81294
Item Type:	Article (Research - C1)
ISSN:	1935-3227
Keywords:	anxiety; depression; hepatitis C virus; people who inject drugs; stress
Copyright Information:	Copyright © 2016 American Society of Addiction Medicine.
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC 568985
Date Deposited:	07 Dec 2023 01:15
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 50% 42 HEALTH SCIENCES > 4203 Health services and systems > 420305 Health and community services @ 30% 52 PSYCHOLOGY > 5203 Clinical and health psychology > 520304 Health psychology @ 20%
SEO Codes:	20 HEALTH > 2003 Provision of health and support services > 200302 Community health care @ 100%
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