Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia
Smith, Simon, Marquardt, Tonia, Jennison, Amy V., D'Addona, Andrew, Stewart, James, Yarwood, Trent, Ho, Jennifer, Binotto, Enzo, Harris, Julian, Fahmy, Mark, Esmonde, Juliet, Richardson, Megan, Graham, Rikki M.A., Gair, Richard, Ariotti, Lawrence, Preston-Thomas, Annie, Rubenach, Sally, O'Sullivan, Siobhan, Allen, Darren, Ragh, Thomas, Grayson, Sachjuan, Manoy, Sophie, Warner, Jeffery M., Meumann, Ella, Robson, Jennifer M., and Hanson, Josh (2023) Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia. Emerging Infectious Diseases, 29 (11). pp. 2218-2228.
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Abstract
Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease. All case-patients had an adverse reaction to oral trimethoprim/sulfamethoxazole treatment, necessitating its discontinuation. We describe the clinical features, environmental sampling, genomic epidemiologic investigation, and public health response to the outbreak. Management of this outbreak shows the potential benefits of making melioidosis a notifiable disease. The approach used could also be used as a framework for similar outbreaks in the future.
| Item ID: | 81237 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1080-6059 |
| Copyright Information: | Emerging Infectious Diseases is an open access journal in the public domain. All content is freely available without charge to the user or his/her institution. Materials published in EID, including text, figures, tables, and photographs, can be reprinted or reused although the journal requests a proper citation be included for its content and users clearly indicate what, if any, changes have been made. |
| Date Deposited: | 02 Apr 2024 02:55 |
| FoR Codes: | 42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100% |
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