Bruenig, Dagmar, Lurie, Janine, Morris, Charles P., Harvey, Wendy, Lawford, Bruce, Young, Ross McD., and Voisey, Joanne (2016) A case-control study and meta-analysis reveal BDNF Val66Met is a possible risk factor for PTSD. Neural Plasticity, 2016. 69794351.

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Abstract

Posttraumatic stress disorder (PTSD) is a debilitating condition that develops in some people after exposure to a traumatic event. Brain-derived neurotrophic factor (BDNF) is highly expressed in the mammalian brain and is thought to be involved in learning and memory processes. A nonsynonymous polymorphism in the BDNF gene, rs6265 (Val66Met), has been hypothesised to be associated with PTSD. Association studies examining the Val66Met polymorphism and PTSD have been inconclusive, likely due to the variability in type of trauma exposure analysed. Vietnam veterans (n = 257) screened for PTSD and controlled for trauma exposure were genotyped for BDNF Val66Met. The association was not significant so we incorporated our data into a meta-analysis to obtain greater statistical power. A comprehensive search of more than 1237 articles revealed eight additional studies suitable for meta-analysis (n = 3625). A random-effects meta-analysis observed a potential protective factor of the Val/Val genotype. After removing two studies with violation of Hardy-Weinberg equilibrium, findings for the Val/Val genotype reached significance. Subgroup analyses confirmed a trend for this finding. Limitations of some studies that inform this meta-analysis include poorly screened controls and a lack of examination of population stratification. Effectively designed studies should inform this line of research in the future.

Item ID:	81137
Item Type:	Article (Research - C1)
ISSN:	1687-5443
Copyright Information:	Copyright © 2016 Dagmar Bruenig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date Deposited:	20 Nov 2023 23:17
FoR Codes:	52 PSYCHOLOGY > 5203 Clinical and health psychology > 520302 Clinical psychology @ 100%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200409 Mental health @ 100%
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