Chanasit, Supapich, Johnston, Elecia, Thanasarnthungcharoen, Chanatip, Kamath, Sandip D., Bohle, Barbara, Lopata, Andreas L., and Jacquet, Alain (2023) Hypoallergenic chimeric virus-like particles for the development of shrimp tropomyosin allergen Pen m 1-specific blocking antibodies. Allergy: European Journal of Allergy and Clinical Immunology. (In Press)

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Abstract

To the Editor Sustained unresponsiveness to peanut by oral immunotherapy (OIT) was associated with the blocking capacity of induced peanut allergen-specific IgG/IgG4 antibodies.1 Currently, approved immu-notherapy for shrimp allergy is lacking. Shrimp sensitizations are only managed by strict avoidance and treatment with adrenaline.Virus-like particles (VLPs) displaying single allergen were shown to be hypoallergenic and to elicit blocking IgG antibody responses.2To develop a new treatment of shrimp allergy, we designed a AP205 capsid protein-based VLP decorated with Pen m 1, the major tropo-myosin allergen from the black tiger shrimp (Penaeus monodon), and using the SpyTag (ST)/SpyCatcher (SC) conjugation system.3 Pen m 1 is a rod-shaped parallel coiled-coil dimeric protein which contains multiple mostly linear IgE-binding epitope.

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