Quinacrine - The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days

Neumayr, Andreas, and Kuenzli, Esther (2023) Quinacrine - The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days. Chimia, 77 (9). pp. 574-576.

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View at Publisher Website: https://doi.org/10.2533/chimia.2023.574
 
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Abstract

Quinacrine, the main antimalarial drug during World War II, has had a chequered history that included the successful repurposing as an intrapleural sclerosant for the treatment of malignant pleural effusions, a nonsurgical method of female sterilisation, and the use as an immunomodulatory drug in lupus erythematosus. While no longer used for these former indications, quinacrine (re)emerged as an indispensable second-line drug for the treatment of nitroimidazole-refractory Giardia duodenalis infections, and thus depicts an indispensable 'orphan drug'.

Item ID: 80904
Item Type: Article (Research - C1)
ISSN: 2673-2424
Keywords: Atabrin, Giardiasis, Mepacrine, Orphan drug, Quinacrine
Copyright Information: This work is licensed under a Creative Commons Attribution 4.0 International License.
Date Deposited: 20 May 2024 23:26
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321499 Pharmacology and pharmaceutical sciences not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 100%
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