Quinacrine - The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days
Neumayr, Andreas, and Kuenzli, Esther (2023) Quinacrine - The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days. Chimia, 77 (9). pp. 574-576.
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Abstract
Quinacrine, the main antimalarial drug during World War II, has had a chequered history that included the successful repurposing as an intrapleural sclerosant for the treatment of malignant pleural effusions, a nonsurgical method of female sterilisation, and the use as an immunomodulatory drug in lupus erythematosus. While no longer used for these former indications, quinacrine (re)emerged as an indispensable second-line drug for the treatment of nitroimidazole-refractory Giardia duodenalis infections, and thus depicts an indispensable 'orphan drug'.
| Item ID: | 80904 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2673-2424 |
| Keywords: | Atabrin, Giardiasis, Mepacrine, Orphan drug, Quinacrine |
| Copyright Information: | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Date Deposited: | 20 May 2024 23:26 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321499 Pharmacology and pharmaceutical sciences not elsewhere classified @ 100% |
| SEO Codes: | 20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 100% |
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