Sikder, Suchandan, Williams, Natasha, Sorenson, Alanna E., Alim, Md A., Vidgen, Miranda E., Moreland, Nicole J., Rush, Catherine M., Simpson, Robert S., Govan, Brenda L., Norton, Robert E., Cunningham, Madeleine E., McMillan, David J., Sriprakash, Kadaba S., and Ketheesan, Natkunam (2017) Group G streptococcus induces autoimmune mediated carditis in the Lewis rat model of Rheumatic Heart Disease. In: [Presented at the 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017]. From: 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017, 16-20 October 2017, Fiji.

PDF (Abstract Only) - Accepted Version Restricted to Repository staff only

Abstract

Acute rheumatic fever and rheumatic heart disease (ARF/RHD) have long been described as autoimmune sequelae of Streptococcus pyogenes or group A streptococcal (GAS) infection. Both antibody and T cell responses against immunodominant GAS virulence factors including M protein, cross-react with host tissue proteins triggering an inflammatory response leading to permanent heart damage. However, in some ARF/RHD endemic regions, throat carriage of GAS is low. As Streptococcus dysgalactiae subspecies equisimilis (SDSE), also known as β-hemolytic groups C and G streptococci (GCS/GGS) also express M-protein, we postulated that streptococci other than GAS may have the potential to initiate or exacerbate ARF/RHD. Using a model initially developed to investigate the uniquely human disease of ARF/RHD, we have now discovered that Streptococcus dysgalactiae or group G streptococcus (GGS) does indeed cause both myocarditis and valvulitis, hallmarks of ARF/RHD. Remarkably the histological, immunological and functional changes in the hearts of rats exposed to GGS are identical to those exposed to GAS. Furthermore, antibody cross-reactivity to cardiac myosin was comparable in both GGS and GAS exposed animals providing additional evidence that GGS can induce and/or exacerbate ARF/RHD.

Item ID:	80655
Item Type:	Conference Item (Abstract / Summary)
Date Deposited:	10 Oct 2023 01:08
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 25% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 25%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
Downloads:	Total: 2
	More Statistics