Sikder, Suchandan, Williams, Natasha, Sorenson, Alanna, Alim, Md Abdul, Vidgen, Miranda, Moreland, Nicole J., Rush, Catherine M., Simpson, Scott, Govan, Brenda L., Norton, Robert E., McMillan, David J., Sriprakash, Kadaba S., and Ketheesan, Natkunam (2018) A Paradigm Shift for Rheumatic Heart Disease: Role of Group G Streptococcus. In: Presented at the 15th International Scientific Conference]. From: 15th International Scientific Conference, 12-13 May 2018, Chattogram, Bangladesh.

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Abstract

Acute rheumatic fever and rheumatic heart disease (ARF/RHD) have long been described as autoimmune sequelae of Streptococcus pyogenes or group A streptococcal (GAS) infection characterised by inflammatory changes to heart, joint, brain, blood vessel and skin tissue. ARF/RHD is considered to be triggered by antibody and T-cell responses against immunodominant GAS virulence factors including M-protein, that cross-react with host tissue proteins. Repeat exposures to GAS perpetuate the autoimmune process leading to permanent cardiac damage. However, in some ARF/RHD endemic regions, there is low carriage of GAS were correspondingly high carriage of Streptococcus dysgalactiae subspecies equisimilis (SDSE), also known as β-hemolytic groups C and G streptococci (GCS/GGS). This has led to the suggestion that SDSE might also have the potential to initiate or exacerbate ARF/RHD. We have discovered using an appropriate model that GGS does indeed cause both myocarditis and valvulitis, hallmarks of ARF/RHD. Remarkably the histological, immunological and functional changes in the hearts of animals exposed to GGS are identical to those exposed to GAS. Furthermore, antibody cross-reactivity to cardiac myosin and collagen I were comparable in both GGS and GAS exposed animals providing further evidence that GGS can induce and/or exacerbate ARF/RHD.

Item ID:	80654
Item Type:	Conference Item (Abstract / Summary)
Date Deposited:	11 Oct 2023 01:24
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 25% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 25%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
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