Thompson, Fintan, Russell, Sarah G, Quigley, Rachel, McDonald, Malcolm, Sagigi, Betty, Taylor, Sean, Campbell, Sandy, Schmidt, Barbara, Esterman, Adrian, Harriss, Linton R., Miller, Gavin, Mills, Phillip, Strivens, Edward, McDermott, Robyn, UNSPECIFIED, and UNSPECIFIED (2023) Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis. Frontiers in Dementia, 2. 1218709.

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Abstract

Objective: Dementia disproportionately affects First Nations populations. Biomarkers collected in primary care may assist with determining dementia risk. Our previous underpowered study showed some suggestive associations between baseline biomarkers with follow-up dementia or cognitive impairment. The current study extended this work with a larger linked dataset.

Study design and setting: Probabilistic data linkage was used to combine four baseline datasets with one follow-up assessment of dementia status 0–20 years later in a First Nations population in Australia. Mixed Effects Generalized Linear Regression models were used to test associations between baseline measures and follow-up status, accounting for repeated measures within individuals.

Results: Linked data were available for 88 individuals, with 101–279 baseline observations, depending on the type of measure. Higher urinary albumin to creatine ratio was associated with greater risk of cognitive impairment/dementia, whereas body weight and key lipid markers were negatively associated. There was no clear trend when these associations were examined by timing of measurement (i.e., ≤10 years or >10 years before a dementia assessment).

Conclusions: The results of this study support findings from our previous work and indicate that microalbuminuria can be an early indicator of dementia risk in this population. The weight and lipid profile findings reflect the mixed results in the published literature and require further investigation and interpretation.

Item ID:	80244
Item Type:	Article (Research - C1)
ISSN:	2813-3919
Copyright Information:	Copyright © 2023 Thompson, Russell, Quigley, McDonald, Sagigi, Taylor, Campbell, Schmidt, Esterman, Harriss, Miller, Mills, Strivens and McDermott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Funders:	National Health and Medical Research Council (NHMRC)
Projects and Grants:	NHMRC GNT1107140, NHMRC GNT1191144, NHMRC GNT1106175, NHMRC GNT0631947
Date Deposited:	04 Sep 2023 04:47
FoR Codes:	42 HEALTH SCIENCES > 4206 Public health > 420699 Public health not elsewhere classified @ 100%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 100%
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