The Utility of Spatial Transcriptomics for Solid Organ Transplantation
Li, Jennifer S.Y., Raghubar, Arti M., Matigian, Nicholas A., Ng, Monica S.Y., Rogers, Natasha M., and Mallett, Andrew J. (2023) The Utility of Spatial Transcriptomics for Solid Organ Transplantation. Transplantation, 107 (7). pp. 1463-1471.
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Abstract
Spatial transcriptomics (ST) measures and maps transcripts within intact tissue sections, allowing the visualization of gene activity within the spatial organization of complex biological systems. This review outlines advances in genomic sequencing technologies focusing on in situ sequencing-based ST, including applications in transplant and relevant nontransplant settings. We describe the experimental and analytical pipelines that underpin the current generation of spatial technologies. This context is important for understanding the potential role ST may play in expanding our knowledge, including in organ transplantation, and the important caveats/limitations when interpreting the vast data output generated by such methodological platforms.
| Item ID: | 79495 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 0041-1337 |
| Copyright Information: | Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| Funders: | National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | NHMRC GNT116877, NHMRC GNT2007991, NHMRC GNT2001315 |
| Date Deposited: | 21 Feb 2024 00:20 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320226 Surgery @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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