Seephonkai, Prapairat, Kaewtong, Chattha, Wangchuk, Phurpa, Jearawuttanakul, Kedchin, Kanjanasirirat, Phongthon, Borwornpinyo, Suparerk, Khulmanee, Tachin, and Patrapuvich, Rapatbhorn (2023) Bioassay-Guided Isolation and Identification of Antiplasmodial Compounds from the Stem Bark of Clausena excavata. Planta Medica. (In Press)

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Abstract

Clausena excavata is a medicinal plant widely distributed in Southeast Asia. It is used for a variety of indications, including to treat malaria. In our present study, a phytochemical study of the methanol extract from the stem bark of C. excavata led to the isolation of five pyranocoumarins, nordentatin (1), dentatin (2), kinocoumarin (3), clausarin (4), and clausenidin (5), and a coumarin, 8-hydroxy-3″,4″-dihydrocapnolactone-2′,3′- diol (6). The isolation of compound 6 from C. excavata and the antiplasmodial activities against a multidrug-resistant K1 strain of Plasmodium falciparum of 1, 3, and 5 were reported for the first time. Compounds 3 and 4 exhibited potent antiplasmodial activities with EC50 values of 1.10 and 0.58 μM, respectively, while 1 and 5 had EC50 values of 5.62 and 7.15 μM, respectively. A prenyl group attached to the C-3 or C-12 position on the pyranocoumarin ring probably plays an important role on the activity. A hydroxyl group at the C-10 position is also likely to enhance the activity.

Item ID:	79328
Item Type:	Article (Research - C1)
ISSN:	1439-0221
Copyright Information:	© 2023. Thieme. All rights reserved.
Date Deposited:	19 Jul 2023 01:19
FoR Codes:	34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340401 Biologically active molecules @ 50% 42 HEALTH SCIENCES > 4208 Traditional, complementary and integrative medicine > 420899 Traditional, complementary and integrative medicine not elsewhere classified @ 50%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 100%
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