A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Wardhani, Kartika, Levina, Aviva, Sun, Biyun, Grau, Georges E.R., Keene, F. Richard, Collins, J. Grant, and Lay, Peter A. (2023) A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium. Chemical Communications, 59. pp. 6877-6880.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: https://doi.org/10.1039/d2cc05827h
 
5


Abstract

A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

Item ID: 78980
Item Type: Article (Research - C1)
ISSN: 1364-548X
Copyright Information: © The Royal Society of Chemistry 2023
Funders: Australian Research Council (ARC), National Health and Medical Research Council (NHMRC)
Projects and Grants: ARC DP180102741, ARC DP210101632, NHMRC APP1099920
Date Deposited: 29 Nov 2023 23:43
FoR Codes: 34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340499 Medicinal and biomolecular chemistry not elsewhere classified @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 100%
Downloads: Total: 5
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page