A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium
Wardhani, Kartika, Levina, Aviva, Sun, Biyun, Grau, Georges E.R., Keene, F. Richard, Collins, J. Grant, and Lay, Peter A. (2023) A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium. Chemical Communications, 59. pp. 6877-6880.
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Abstract
A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
| Item ID: | 78980 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1364-548X |
| Copyright Information: | © The Royal Society of Chemistry 2023 |
| Funders: | Australian Research Council (ARC), National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | ARC DP180102741, ARC DP210101632, NHMRC APP1099920 |
| Date Deposited: | 29 Nov 2023 23:43 |
| FoR Codes: | 34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340499 Medicinal and biomolecular chemistry not elsewhere classified @ 100% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 100% |
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