EAACI Molecular Allergology User's Guide 2.0

Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P., Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G., Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, and Matricardi, Paolo M. (2023) EAACI Molecular Allergology User's Guide 2.0. Pediatric Allergy and Immunology, 34 (S28). e13854.

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Abstract

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

Item ID: 78970
Item Type: Article (Research - C1)
ISSN: 1399-3038
Keywords: allergy, allergy diagnosis, anaphylaxis, asthma, atopic dermatitis, basophil activation test, component-resolved diagnosis, cross-reactive carbohydrates, diagnostic algorithms, food allergy, gibberellin-regulated proteins, IgE, IgE cross-reactivity, lipocalins, microarray, molecular allergology, non-specific lipid transfer proteins, oleosins, pan-allergens, parvalbumins, pathogenesis-related protein family 10, polcalcins, pollen allergy, precision medicine, profilins, seed storage proteins, serum albumins, tropomyosins
Copyright Information: © 2023 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Date Deposited: 11 Jan 2024 07:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 100%
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