Sex Differences in Psychosis: Focus on Animal Models

Gogos, Andrea, and van den Buuse, Maarten (2023) Sex Differences in Psychosis: Focus on Animal Models. In: Gibson, Claire, and Galea, Liisa A.M., (eds.) Sex Differences in Brain Function and Dysfunction. Current Topics in Behavioral Neurosciences, 62 . Springer, Cham, Switzerland, pp. 133-163.

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Abstract

Most psychiatric illnesses, such as schizophrenia, show profound sex differences in incidence, clinical presentation, course, and outcome. Fortunately, more recently the literature on sex differences and (to a lesser extent) effects of sex steroid hormones is expanding, and in this review we have focused on such studies in psychosis, both from a clinical/epidemiological and preclinical/animal model perspective. We begin by briefly describing the clinical evidence for sex differences in schizophrenia epidemiology, symptomatology, and pathophysiology. We then detail sex differences and sex hormone effects in behavioral animal models of psychosis, specifically psychotropic drug-induced locomotor hyperactivity and disruption of prepulse inhibition. We expand on the preclinical data to include developmental and genetic models of psychosis, such as the maternal immune activation model and neuregulin transgenic animals, respectively. Finally, we suggest several recommendations for future studies, in order to facilitate a better understanding of sex differences in the development of psychosis.

Item ID: 78522
Item Type: Book Chapter (Research - B1)
ISBN: 978-3-031-26723-9
ISSN: 1866-3389
Keywords: Developmental models, Estradiol, Female, Genetic models, Locomotor hyperactivity, Male, Prepulse inhibition, Schizophrenia
Copyright Information: © 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG.
Date Deposited: 04 Jan 2024 07:11
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 50%
52 PSYCHOLOGY > 5202 Biological psychology > 520201 Behavioural genetics @ 50%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280121 Expanding knowledge in psychology @ 100%
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