Coagulopathy is an under-recognised complication of acquired HLH
Kosciejew, Serena, Morris, Edward, and Wight, Joel (2023) Coagulopathy is an under-recognised complication of acquired HLH. BMJ Case Reports, 16 (1). e251860.
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Abstract
Acquired haemophagocytic lymphohistiocytosis (aHLH) is a rare and often fatal process of uncontrolled cytokine release driven by the inability of natural killer cells to eliminate infected or malignant cells. Herein, we report two cases of aHLH complicated by bleeding secondary to coagulopathy due to hypofibrinogenaemia and thrombocytopenia despite appropriate correction with blood products. These cases highlight the effect coagulopathy and thrombocytopenia can have on patient outcomes when trying to confirm and manage the underlying process driving aHLH.
| Item ID: | 78455 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1757-790X |
| Keywords: | Haematology (incl blood transfusion), Malignant and Benign haematology |
| Copyright Information: | © BMJ Publishing Group Limited 2023. |
| Date Deposited: | 12 Dec 2023 07:13 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320102 Haematology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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