EBNEO Commentary: Safety and efficacy of erythropoietin in neonates with hypoxic–ischaemic encephalopathy
Chung, Lorraine Marie, and Hariharan, Gopakumar (2023) EBNEO Commentary: Safety and efficacy of erythropoietin in neonates with hypoxic–ischaemic encephalopathy. Acta Paediatrica, 112 (4). pp. 885-886.
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Abstract
Therapeutic hypothermia remains the only proven treatment to improve mortality and morbidity in neonates with hypoxic–ischaemic encephalopathy (HIE). Preclinical models have demonstrated erythropoietin as a potential adjuvant therapy in neonatal HIE due to its neuroprotective and neuro-regenerative effects. The anti-inflammatory and anti-oxidant effects of erythropoietin promotes neurogenesis through remodelling of brain tissue after HIE. The neuroprotective effects of erythropoietin result from its binding to erythropoietin receptors on mature neurons and neuronal progenitors causing induction of antiapoptotic genes.
| Item ID: | 78343 |
|---|---|
| Item Type: | Article (Short Note) |
| ISSN: | 1651-2227 |
| Copyright Information: | © 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. |
| Date Deposited: | 02 Jan 2024 06:18 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321303 Neonatology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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