Both low and high levels of low-density lipoprotein cholesterol are risk factors for diabetes diagnosis in Chinese adults

Yang, Guang, Qian, Tingting, Sun, Hui, Xu, Qun, Hou, Xujuan, Hu, Wenqi, Zhang, Guang, Fang, Yan, Song, David, Chai, Zhonglin, Magliano, Dianna J., Golledge, Jonathan, and Wang, Yutang (2022) Both low and high levels of low-density lipoprotein cholesterol are risk factors for diabetes diagnosis in Chinese adults. Diabetes Epidemiology and Management, 6. 100050.

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Abstract

Aims: This study aimed to investigate whether both high and low levels of low-density lipoprotein cholesterol (LDL-C), i.e., hypercholesterolemia and hypocholesterolemia, were associated with diabetes in Chinese adults.

Methods: This cross-sectional study included 22,557 Chinese adults. The LDL-C reference interval was determined from a healthy sub-cohort. Associations between hypocholesterolemia or hypercholesterolemia with diabetes were analyzed using binary logistic regression.

Results: The LDL-C reference interval was 1.48–3.77 mmol/L (57.23–145.78 mg/dL). Therefore, hypocholesterolemia, normocholesterolemia, and hypercholesterolemia were defined as an LDL-C concentration of <1.48, 1.48–3.77, and >3.77 mmol/L, respectively. Prevalence of diabetes was higher in people with hypocholesterolemia or hypercholesterolemia than that in people with normocholesterolemia. Hypocholesterolemia was associated with an increased multivariable-adjusted risk for diabetes diagnosis (odds ratio, 1.57; 95% confidence interval, 1.18–2.08), and so was hypercholesterolemia (odds ratio, 1.29; 95% confidence interval, 1.10–1.51). The results remained significant after exclusion of those who took lipid-lowering drugs from the analysis.

Conclusions: This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes .

Item ID: 78263
Item Type: Article (Research - C1)
ISSN: 2666-9706
Keywords: Diabetes mellitus, Dyslipidemia, Low-density lipoprotein, Reference interval, risk factor
Copyright Information: © 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC grant 1062671, NHMRC Practitioner Fellowship 1117061
Date Deposited: 10 May 2023 00:59
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320299 Clinical sciences not elsewhere classified @ 100%
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