Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis
Gusman, David Jonathan R., Mello-Neto, João M., Alves, Breno Edson S., Matheus, Henrique R., Ervolino, Edilson, Theodoro, Leticia H., and de Almeida, Juliano M. (2018) Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 76. pp. 147-159.
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Abstract
Background and objective: Despite clinical trials and reviews attempt to assess a possible relationship between dementia and periodontal disease, no meta-analysis has been performed and this issue remains undetermined. The aim of this study is to conduct a systematic review and meta-analysis to assess severity of periodontitis in subjects with dementia.
Methods: The search was conducted in Pubmed, Embase/MEDLINE. Two independent reviewers extracted data and assessed the risk bias (Newcastle–Ottawa scale). Meta-analyses were performed using the means of probing depth (PD) and clinical attachment loss (CAL) in patients with or without dementia. The mean difference were analyzed (P ≤ 0.05).
Results: Fourteen studies were included in the systematic review. In the qualitative analysis, most studies reported higher prevalence of periodontal disease in dementia patients. The studies had low risk of bias and two meta-analyses were performed for each parameter, including or not a cross-sectional study. The meta-analyses including the cross-sectional study demonstrated significant association between dementia and periodontal disease (mean difference: PD = 1.41; CAL = 1.40, P < 0.05), however, it wasn't confirmed when the cross-sectional study was removed (1.25 mm, P < 0.22) and CAL (1.20 mm, P < 0.22).
Conclusion: Although the qualitative analysis have suggested worse periodontal conditions in dementia patients, due to different study types and the high heterogeneity among them, the meta-analysis does not support the association between dementia and severity of periodontal disease.
| Item ID: | 77864 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1872-6976 |
| Keywords: | Dementia, Meta-analysis, Periodontal disease, Systematic review |
| Copyright Information: | Published Version: © 2018 Elsevier B.V. All rights reserved. Accepted Version: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Date Deposited: | 21 Mar 2023 22:14 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320310 Periodontics @ 70% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320999 Neurosciences not elsewhere classified @ 30% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50% 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 50% |
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