The effectiveness of the low-level laser, antibiotic and surgical therapy in the treatment of medication-related osteonecrosis of the jaws: A case report

Del Pilar Rodríguez-Sánchez, Maria, Statkievicz, Cristian, de Mello-Neto, João Martins, Toro, Luan Felipe, Bassi, Ana Paula Farnezzi, Garcia, Valdir Gouveia, Theodoro, Letícia Helena, and Ervolino, Edilson (2020) The effectiveness of the low-level laser, antibiotic and surgical therapy in the treatment of medication-related osteonecrosis of the jaws: A case report. Journal of Lasers in Medical Sciences, 11 (1). pp. 98-103.

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Introduction: Bisphosphonates consist of a range of drugs used in the treatment of osteopathy or some osteotropic malignancies. Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse consequence of their use. Conventional treatment is not always effective, so it is necessary to resort to the use of adjuvant therapies. This study aimed to evaluate the effectiveness of the association of surgery, antibiotic therapy and low-level laser (LLL) therapy as a treatment strategy for MRONJ through the presentation of a clinical case.

Case Presentation: A 49-year-old female patient presented for the diagnosis and treatment of bone lesions in the maxillae. The patient reported that she had used zoledronate for 1 year. Five years later there were 2 painless bone lesions on both sides of the maxilla, following the extraction of the first upper molars. Clinical, tomographic and histopathologic examination established the diagnosis of MRONJ. The treatment consisted of the curettage of the necrotic bone, antibiotic and thirteen LLL therapy sessions. Integral mucosal healing was observed after a two-month follow-up and no symptoms were detected. The patient was evaluated at 6 and 12 postoperative months without complications.

Conclusion: The combination of surgery, antibiotic therapy, and LLL therapy has shown to be effective in the treatment of MRONJ.

Item ID: 77857
Item Type: Article (Research - C1)
ISSN: 2228-6721
Keywords: Anti-bacterial agents, Diphosphonates, Laser therapy, Oral surgical procedures, Osteonecrosis
Copyright Information: Copyright: Laser application in Medical Sciences Research Center is the copyright owner of the material published in the JLMS. However, all published works are open access and are immediately available without cost to anyone on the Journal’s website. The users are free to use the work, subject to proper attribution of authorship and ownership of the rights. Authors may use their material in presentations and subsequent publications they write or edit themselves, provided that the JLMS is notified in writing and is acknowledged as the original publication.
Date Deposited: 11 Jul 2023 23:14
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320301 Craniofacial biology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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