Suvarna, Beena (2013) Adenosine Receptors as Targets for Therapeutic Intervention. Kathmandu University Medical Journal, 11 (1). pp. 96-101.

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Abstract

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the world. There is growing evidence that they could also be promising therapeutic targets in a wide range of conditions, including cerebral and cardiac ischaemic diseases, sleep disorders, immune and inflammatory disorders and cancer. After more than three decades of medicinal chemistry research, a considerable number of selective agonists and antagonists of adenosine receptors have been discovered, and some have been clinically evaluated, although none has yet received regulatory approval. However, recent advances in the understanding of the roles of the various adenosine receptor subtypes, and in the development of selective and potent ligands, as discussed in this review, have brought the goal of therapeutic application of adenosine receptor modulators considerably closer.

Item ID:	77801
Item Type:	Article (Research - C1)
ISSN:	4812-2078
Copyright Information:	This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
Date Deposited:	26 May 2023 00:38
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321404 Pharmaceutical delivery technologies @ 100%
SEO Codes:	24 MANUFACTURING > 2408 Human pharmaceutical products > 240803 Human pharmaceutical treatments @ 25% 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 70% 20 HEALTH > 2002 Evaluation of health and support services > 200202 Evaluation of health outcomes @ 5%
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