Suvarna, Beena (2013) Sirtuins: The Future Insight. Kathmandu University Medical Journal, 10 (2). pp. 77-82.

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Abstract

Sirtuins are evolutionary conserved NAD+ dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins represent a promising new class of III NAD dependent histone deacetylases that regulate a number of physiological processes, originally identified in yeast. Sirtuins regulate various normal and abnormal cellular and metabolic processes, including tumorgenesis, neurodegeneration and processes associated with type 2 diabetes and obesity. Several age-related diseases such as Alzheimer’s disease and longevity have also been linked to the functions of sirtuins. Because of these associations, the identification of small molecules sirtuin modulators has been of significant interest.

Item ID:	77797
Item Type:	Article (Research - C1)
ISSN:	1812-2078
Copyright Information:	This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
Date Deposited:	26 May 2023 00:55
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 100%
SEO Codes:	20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
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