Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial

Rostami, Maryam, Tehrani, Fahimeh Ramezani, Simbar, Masoumeh, Bidhendi Yarandi, Razieh, Minooee, Sonia, Hollis, Bruce W., and Hosseinpanah, Farhad (2018) Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. Journal of Clinical Endocrinology & Metabolism, 103 (8). pp. 2936-2948.

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Context: Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of routine prenatal care.

Objective: We sought to determine the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D [25(OH)D] levels and preventing pregnancy complications. Also, to identify a safe regimen, we compared several regimens in a subgroup of vitamin D–deficient pregnant women.

Design: Two cities of Masjed-Soleyman and Shushtar from Khuzestan province, Iran, were selected as the screening and nonscreening arms, respectively. Within the screening arm, a randomized controlled trial was conducted on 800 pregnant women.

Setting: Health centers of Masjed-Soleyman and Shushtar cities.

Patients or Participants: Pregnant women aged 18 to 40 years.

Intervention: Women with moderate [25(OH)D, 10 to 20 ng/mL] and severe [25(OH)D, <10 ng/mL] deficiency were randomly divided into four subgroups and received vitamin D3 (D3) until delivery.

Main Outcome Measure: Maternal concentration of 25(OH)D at delivery and rate of pregnancy complications

Results: After supplementation, only 2% of the women in the nonscreening site met the sufficiency level (>20 ng/mL) vs 53% of the women in the screening site. Adverse pregnancy outcomes, including preeclampsia, gestational diabetes mellitus, and preterm delivery, were decreased by 60%, 50%, and 40%, respectively, in the screening site. A D3 injection in addition to monthly 50,000 IU maintenance therapy contributed the most to achievement of sufficient levels at delivery.

Conclusions A prenatal vitamin D screening and treatment program is an effective approach in detecting deficient women, improving 25(OH)D levels, and decreasing pregnancy adverse outcomes.

Item ID: 77748
Item Type: Article (Research - C1)
ISSN: 1945-7197
Copyright Information: Copyright © 2018 Endocrine Society
Date Deposited: 28 Nov 2023 04:25
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3215 Reproductive medicine > 321502 Obstetrics and gynaecology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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