Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease
Mahan, Brandon, Tacail, Theo, Lewis, Jamie, Elliott, Tim, Habekost, Mette, Turner, Simon, Chung, Roger, and Moynier, Frédéric (2022) Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease. Metallomics, 14 (12). mfac090.
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Abstract
Natural stable metal isotopes have shown utility in differentiation between healthy and diseased brain states (e.g. Alzheimer's disease, AD). While the AD brain accumulates some metals, it purges others, namely K (accompanied by increased serum K, suggesting brain–blood transferal). Here, K isotope compositions of Göttingen minipig brain regions for two AD models at midlife are reported. Results indicate heavy K isotope enrichment where amyloid beta (Aβ) accumulation is observed, and this enrichment correlates with relative K depletion. These results suggest preferential efflux of isotopically light K+ from the brain, a linkage between brain K concentrations and isotope compositions, and linkage to Aβ (previously shown to purge cellular brain K+). Brain K isotope compositions differ from that for serum and brain K is much more abundant than in serum, suggesting that changes in brain K may transfer a measurable K isotope excursion to serum, thereby generating an early AD biomarker.
Item ID: | 77214 |
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Item Type: | Article (Research - C1) |
ISSN: | 1756-591X |
Keywords: | Alzheimer's disease, brain potassium, isotope geochemistry, isotope metallomics, neurodegeneration, porcine model |
Copyright Information: | © The Author(s) 2022. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Date Deposited: | 11 Jan 2023 09:02 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320503 Medical biochemistry - inorganic elements and compounds @ 100% |
SEO Codes: | 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100% |
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